Estradiol (E2) Test

An Estradiol (E2) blood test measures the level of the hormone Estradiol, also known as estradiol, in a blood sample. It is the primary form of oestrogen (also referred to as estrogen) and plays a key role in sexual development. Oestrogen is a group of sex hormones produced in both men and women, but at much higher levels in women. Estradiol (E2) is one of the four types of oestrogen—along with oestrone (E1), oestriol (E3), and oestetrol (E4)—and is the most potent and predominant form of oestrogen in women during the reproductive years. Estradiol levels provide valuable insights into ovarian function, aiding in the assessment of menstrual issues such as missed periods or irregular bleeding. Doctors may order an Estradiol test if puberty occurs earlier or later than anticipated. Additionally, this test can help identify damage or disease in the testes, ovaries, or adrenal glands. It is also used to monitor pregnancies or fertility treatments, and evaluate symptoms of menopause. If you live and are experiencing issues related to abnormal Estradiol levels, schedule an Estradiol (E2) test today. This can help doctors identify hormonal issues early and begin treatment promptly.

What the 2 parameters cover

Typical reference ranges — your report marks anything outside them:

Since Estradiol plays a crucial role in sexual development and reproductive health, the Oestrogen test may be ordered for the following reasons: Assess how well the ovaries, placenta, or adrenal glands are functioning. Evaluate abnormal development of male or female body characteristics. Investigate the cause of missed periods, abnormal bleeding, or stopped menstrual periods. Determine the cause of infertility. Monitor a pregnancy or check a woman's response to fertility treatments such as ART. Evaluate menopause symptoms such as hot flashes. Monitor the effectiveness of hormone therapy in menopausal women. Detect damage or disease in the testes, ovaries, or adrenal glands. Diagnose early puberty in adolescents. Monitor individuals with hypopituitarism (underactive pituitary gland). Investigate problems caused by abnormal oestrogen levels such as gynaecomastia (non-cancerous breast tissue development in males), ovarian tumour, and breast cancer. Note : Human sex hormones function closely with each other. So, an Estradiol test is often performed with other blood tests that measure the levels of luteinising hormone (LH), follicle-stimulating hormone (FSH), prolactin, testosterone, progesterone, thyroid-stimulating hormone (TSH), and free thyroxine (FT4). 5,6 The combined results help doctors gain a more comprehensive understanding of sexual maturation and reproductive health in an individual.

Understanding your report

What your results can mean — always review them with your doctor:

The table below provides the normal range for Estradiol levels in picograms per millilitre (pg/mL).